Krebs cycle = TCA cycle = citric acid cycle

Preparatory step between glycolysis and a Krebs cycle:

C02 molecule removed from pyruvate leaving a two carbon acetyl molecule

Acetyl + coenzyme A = acetyl CoA

This reaction is irreversible

Krebs cycle:

acetyl CoA + oxaloacetate (0AA) = citric acid (6C)

Citric acid is converted to isocitrate (6C)

Isocitrate is converted to a alpha-ketogluterate (5C)

CO2 is given off and an NAD molecule is reduced to NADH

Alpha-ketogluterate is converted to succinyl CoA (4C)

CO2 is given off and an NAD molecule is reduced to NADH

SuccinylCoA is converted to succinate (4C)

ADP is phosphorylated to ATP

Succinate is converted to fumerate(4C)

FAD is reduced to FADH2

Fumerate is converted to malate (4C)

Malate is converted to oxaloacetate(4C)

NAD is reduced to NADH

Find out which enzymes capitalize each of these steps



Lab exercise

Phosphoglucomutase capitalizes the conversion of glucose-1-phosphate to glucose-6-phosphate

In animals, phosphoglucomutase has a phosphate attached

In plants, phosphoglucomutase does not always have a phosphate attached

Phosphoglucomutase must have a phosphate attached in order to work right

The phosphate on the phosphoglucomutase is given up to the glucose-1-phosphate making a glucose-1,6-this phosphate

The phosphate in the number one position comes off and attaches to PGM, making a glucose-6-phosphate molecule

If the phosphoglucomutase is not phosphorylated a phosphate must be added to the reaction.

Glucose-1,6-bisphosphate was used in your reaction to supply the phosphate